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KMID : 0357119810030010015
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Korean Journal of Immunology
1981 Volume.3 No. 1 p.15 ~ p.24
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Effect of Concanavalin A on Cell-mediated and Humoral Immune Responses
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張友鉉/Chang, Woo Hyun
金翼詳/李明洙/崔明植/Kim, Ik Sang/Lee, Myung Soo/Choi, Myung Sik
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Abstract
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Mice treated with Con A 1 or 2 days prior to primary immunization with SRBC exhibited a significai.F suppression of direct PFC response. This immunosuppressive effect could be reversed by using higher doses of antigen designad to by pass T-cell function. Normal syngeneic recipient mice transferred with Con A-activated spleen cells showed a suppression of primary direct PFC response on day 6. Recipients transferred with Con A-activated thymocytes showed no effect on direct PFC responses.
It is suggested that Con A induced immunosuppression of thymus-dependent humoral immune response in mice is at least partly due to the activation of a subpopulation of thymus derived cells, of which tissue source is not thymus but spleen, and that the effect is short-lived and the suppressive effect of HIR is marked in late stage.
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